Portail Guide

4. What is the impact of topical corticosteroids on wound healing?

Topical corticosteroids play a key role in the treatment of hyper-granulating wounds (Figure 3). They reduce exuberant granulation tissue and its epidermalization, which is otherwise impossible for mechanical reasons. Although often feared by practitioners, they do not cause infectious complications in chronic wounds and can be a valuable aid.

They do delay healing, unlike systemic corticosteroids.

However, at high doses and with prolonged use (e.g. in the treatment of autoimmune bullous dermatoses), they can cause skin atrophy, resulting in skin tears at the slightest trauma.

Figure 3. Hyper-granulation ulcer requiring the application of topical corticosteroids.


1. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999;341: 738-46.

2. Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol2007; 127: 514-25.

3. Suivi en ville des plaies chroniques : ulcère veineux de jambe, escarre, plaie du pied diabétique. Assurance maladie, octobre 2015.

4. Plaies aiguës en structure d’urgence. Référentiel de bonnes pratiques. SFMU, 2017: 32 p.

5. Sgonc R, Gruber J. Age-related aspects of cutaneous wound hea- ling: a mini-review. Gerontology 2013; 59: 159-64.

6. Majtan J. Honey: an immunomodulator in wound healing. Wound Repair Regen 2014; 22: 187-92.

7. Opletalová K, BlaizotX, Mourgeon B, et al. Maggot therapyfor wound debridement: a randomized multicenter trial. Arch Dermatol 2012; 148: 432-8.

8. van den Broek LJ, Limandjaja GC, Niessen FB, Gibbs S. Human hypertrophic and keloid scar models: principles, limitations and future challenges from a tissueengineering perspective. ExpDer- matol 2014; 23: 382-6.

9. Prise en charge de l’ulcère de jambe à prédominance veineuse hors pansement. Recommandations HAS, 2006.

10. La compression médicale dans les affections veineuses chroniques. Fiche de bon usage HAS, 2010.

11. Edmonds M, Lázaro-Martínez JL, Alfayate-García JM, et al. Sucrose octasulfate dressing versus control dressing in patients with neu- roischaemic diabetic foot ulcers (Explorer): an international, multi- centre, double-blind, randomised, controlled trial [published correction appears in Lancet Diabetes Endocrinol 2018]. Lancet Diabetes Endocrinol 2018; 6: 186-96.

12. Reinholz M, Poetschke J, Schwaiger H, Epple A, Ruzicka T, Gauglitz GG. The dermatology life quality index as a means to assess life quality in patients with different scar types. J Eur Acad Dermatol Venereol2015; 29: 2112-9.

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